NeuroMab™ Anti-TRAK2 BBB Shuttle Antibody, Clone N390/43

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TRAK2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 757-914 (C-terminus) of human TRAK2 (also known as Trafficking kinesin-binding protein 2, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein, GABA-A receptor-interacting factor 1, O-GlcNAc transferase-interacting protein of 98 kDa, EMBL AAH60681.1, Ensembl ENSMUSP00000027186 MGI 1918077, Als2cr3, Grif1, Oip98 and KIAA0549, accession number O60296)
Rat: 84% identity (134/159 amino acids identical)
Mouse: 84% identity (134/159 amino acids identical)
<50% identity with TRAK1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N390/43

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with TRAK1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

TRAK2

Official Name

TRAK2

Full Name

TRAK2

Alternative Names

Trafficking Kinesin Protein 2; Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein; Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region; Candidate 3; O-Linked N-Acetylglucosamine Transferase Interacting Protein 98; Gamma-Aminobutyric Acid(A) Receptor-Interacting Factor; Trafficking Protein; Kinesin Binding 2; ALS2CR3; Trafficking Kinesin-Binding Protein 2; Milton Homolog 2 (Drosophila);

Uniprot ID

O60296

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with untagged TRAK1, GFP-tagged TRAK2 or untagged Kv2.1 plasmid probed with N390/43 (left) or N52A/42 (right) TC supe.