NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P1397)
Functional antibody against Human TREM2
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Agonist; FC; In Vitro
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Lot Number
SPECIFIC INQUIRY
inquiryDescription
Immunogen
Species Reactivity
Clonality
Host Species
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
Storage
Research Use Only
Figure 1 shows protein levels of the inflammatory cytokines IL-6 and TNFα, which are secreted in response to WT, TREM2 heterozygous (Het), and TREM2 KO macrophages stimulated with the cytokines IL-4 or IFNg.
Figure 2 shows DAP12 phosphorylation measured by Western blot in wild-type and TREM2-deficient (TREM2-/-) mouse macrophages following incubation with the TREM2 antibody Ab21.
Figure 3 shows the protein levels of the inflammatory cytokines TNFa, IL-6, IL-10 and MCP-1 secreted in response to stimulation of WT and TREM2 KO macrophages with the inflammatory mediators LPS or zymosan.
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