NeuroMab™ Mouse Anti-Human Cytokeratin Monoclonal Antibody (CBP2385)

Product Overview

Description

This antibody has been shown to detect cytokeratins 7, 8, 18, and 19 and may detect other keratins as well. It does not exhibit cross-reactivity with non-epithelial cells or tissues such as glial and other cells in the brain and the central nervous system. This distinguishes it from the pan cytokerain antibodies (clones AE-1 and AE-3). In normal tissues, it does not stain the superficial layers of the epidermis which suggests it does not detect keratin 1 and keratin 10.

Immunogen

This antibody was developed using a crude cytokeratin extract prepared from RT-4 and MCF-7 cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP2385

Applications

IHC

Application Notes

IHC (≥1:40)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1755

Product Properties

Form

Liquid

Formulation

PBS with BSA and 0.1% NaN3

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.