NeuroMab™ Anti-GABABR2 GABA-B receptor, Clone N81/37 (CBP8227)

Product Overview

Immunogen

Fusion protein amino acids 862-913 (cytoplasmic C-terminus) of human GABABR2 (also known as Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, Gb2, G-protein coupled receptor 51 or GPR51, accession number O75899)
Mouse: 100% identity (52/52 amino acids identical)
Rat: 100% identity (52/52 amino acids identical)
<20% identity with GABABR1

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

CBP8227

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with GABABR1

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABBR2

Official Name

GABBR2

Full Name

GABA(B)R2

Alternative Names

Gamma-Aminobutyric Acid Type B Receptor Subunit 2; Gamma-Aminobutyric Acid (GABA) B Receptor; 2; G-Protein Coupled Receptor 51; GABA-B Receptor 2; GABA-B-R2; GABA-BR2; GABABR2; GPRC3B;

Uniprot ID

O75899

Product Pictures

Fig. 1 Adult rat brain membrane immunoblot.

Fig. 2 Immunoblot against membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N81/37 (left) or N52A/42 (right) TC supe.

Fig. 3 Immunoblot against brain membrane fractions from rat (RBM) and from GABABR2 knockout (KO) and wild-type (WT) mice probed with N81/37 (left) or N52A/42 (right) TC supe.

IHC

Fig. 4 Adult rat brain immunohistochemistry.

IEM

Fig. 5 Electron micrograph of N81/37 labelling in stratum radiatum of mouse hippocampal CA1 using a pre-embedding immunogold method. Immunoparticles are seen at postsynaptic sites (arrows) along the extrasynaptic plasma membrane of dendritic spines (s) and shafts of pyramidal cells forming synaptic contacts with excitatory axon terminals (b), and at presynaptic sites (arrowheads) in excitatory axon terminals (b).

Publications