Human HEK293T/NMU2 Stable Cell Line

[CAT#: NCL20120092CR]

Neuromedin U Receptor 2 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

NMU1 and NMU2 are two G-protein coupled receptors binding to Neuromedin U (NmU) that is a peptide which regulates peripheral functions such as smooth muscle contraction and blood pressure, and CNS functions including nociception and feeding activity. Compared to the wide distribution of NMU1 in peripheral tissue, expression of NMU2 receptor is limited to areas of the brain, such as the paraventricular nucleus, along the wall of the third ventricle in the hypothalamus and the CA1 region of the hippocampus, and to the spinal cord.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 100 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

NMU2

Family

Neuromedin receptor

Strain

NMU2 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

NMU2

Official Name

NMU2

Alternative Names

NMU2 receptor; FM-4; FM4; SNORF72; G-protein coupled receptor TGR-1; G-protein-coupled receptor FM-4; neuromedin U receptor 2; NMU-R2; TGR-1; NMU2R

Gene ID

4831(Human); 18103(Mouse); 83782(Rat)

Uniprot ID

P22392(Human); Q01768(Mouse); P19804(Rat)

References

1. Sampson, C. M., Kasper, J. M., Felsing, D. E., Raval, S. R., Ye, N., Wang, P.,.. & Hommel, J. D. (2018). Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models. Pharmacology research & perspectives, 6(5), e00425.

Publications