Human Neuroblastoma SH-SY5Y Cell Line

[CAT#: NCL-2108-P027]

Neuroblast from neural tissue

Species:: Human

Applications:: Cell Culture

Cell Types:: Tumor Cells

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Product Overview

Description

A bone marrow biopsy-derived sub-line called SH-SY5Y was triple-cloned. Dopamine-hydroxylase activity in SH-SY-5Y enables it to transform glutamate into the neurotransmitter GABA. will take 3-4 weeks for naked mice to develop tumours. With more passages, the loss of neuronal properties has been described. Therefore, it is advised to routinely check certain characteristics like noradrenalin uptake or neuronal markers.

Neurological Disease Models

AD-related Cells; Brain Tumor-related Cells; PD-related Cells

Cell Types

Tumor Cells

Applications

Cell Culture

Application Notes

SH-SY5Y cell line human is used for neurotransmitter studies. SH-SY5Y cell line human has been used to:
study the iron-mediated toxicity of amyloid β peptide
check the significance of anionic luminescent conjugated polythiophene (LCP) polythiophene acetic acid (PTAA) in vital staining of cells
study the effect of haloperidol on sigma-1 receptors in guinea pig brain and human neuroblastoma cells