IonON™ Human Kv7.3/Kv7.5 Recombinant Stable Cell Line

[CAT#: NCL-7P104]

Creative Biolabs provides numerous IonON cell models of ion channels to meet your drug discovery needs.

Species:: Human

Applications:: Ion Channel Assay

Cell Types:: Other Cells

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Product Overview

Description

The potassium voltage-gated channel KCNQ5, a member of the KQT-like subfamily, is encoded by the KCNQ5 gene (also known as Kv7.5). This gene, which is found in both the brain and skeletal muscle, belongs to the KCNQ potassium channel gene family. When depolarization occurs, the current produced by the protein encoded by this gene slowly activates, and it can combine with the protein represented by the KCNQ3 gene to form a heteromerization channel. Both the M current and the current expressed by this protein are voltage- and inhibitor-dependent. M1 muscarinic receptor activation also inhibits them. For this gene, many transcript variants have been found that encode various isotypes.

Cell Types

Other Cells

Applications

Ion Channel Assay

Application Notes

Electrophysiology assay (Conventional and automated patch clamp platforms)

Species

Human

Properties

Size

2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Target Details

Target

Kv7.3/Kv7.5

Official Name

KCNQ3

Full Name

Kv7.3/Kv7.5

Alternative Names

Potassium Voltage-Gated Channel Subfamily Q Member 3; Potassium Channel; Voltage Gated KQT-Like Subfamily Q; Member 3; Potassium Voltage-Gated Channel; KQT-Like Subfamily; Member 3; Voltage-Gated Potassium Channel Subunit Kv7.3; Potassium Channel Subunit Alpha KvLQT3; Potassium Channel; Voltage-Gated; Subfamily Q; Member 3;

Publications