NeuroMab™ Anti-ASCL1 BBB Shuttle Antibody(NRZP-1022-ZP3676)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; IHC

Relevant Diseases

Glioblastoma

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

ASCL1

Official Name

ASCL1

Full Name

Achaete-Scute Family BHLH Transcription Factor 1

Alternative Names

Achaete-Scute Family BHLH Transcription Factor 1; Class A Basic Helix-Loop-Helix Protein 46; BHLHa46; ASH-1; HASH1; ASH1; Achaete-Scute Complex (Drosophila) Homolog-Like 1; Achaete-Scute Complex Homolog 1 (Drosophila);

Product Pictures

IHC

Figure 1 provides in tabular form microarray and immunohistochemistry (IHC) results of ASCL1 expression in various lung, colorectal, and pancreatic cancer PDX samples, where the IHC results were generated using exemplary antibodies.

ELISA

Figure 2 provides evidence in tabular form for ASCL1 antibody binding data using various ELISA assays using samples that allow for intracellular antigen binding (IC ratio), cell lysate (CL ratio), and purified antigen (ELISA positive ratio)

Publications