NeuroMab™ Anti-BAF53a BBB Shuttle Antibody, Clone N336B/83

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ACTL6A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 43-119 (MVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENME AISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHP, actin subdomain 2) of human BAF53a (also known as 53 kDa BRG1-associated factor A, BRG1-associated factor 53A, Actin-like protein 6A, ArpNbeta, ACTL6A, INO80 complex subunit K and INO80K, accession number O96019)
Mouse: 96% identity (74/77 amino acids identical)
Rat: 94% identity (73/77 amino acids identical)
>50% identity with BAF53a

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N336B/83

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with BAF53b

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ACTL6A

Official Name

ACTL6A

Full Name

BAF53a

Alternative Names

ACTL6A; ACTL6; ARPN-BETA; Arp4; BAF53A; INO80K; actin like 6A; SMARCN1

Uniprot ID

O96019

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged BAF53a, BAF53b or Kv2.1 plasmids and probed with N336B/83 (left) or N52A/42 (right) TC supe. Note that BAF53a is ubiquitously expressed in many different cell types, including COS cells.

Publications