NeuroMab™ Anti-BAF53b BBB Shuttle Antibody, Clone N332B/15

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-ACTL6B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 39-114 (TTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDGAEV MSPLKNGMIEDWECFRAILDHTYSKHVKSEPNL, actin subdomain 2) of human BAF53b (also known as 53 kDa BRG1-associated factor B, BRG1-associated factor 53B, Actin-like protein 6B, ArpNalpha, ACTL6B and ACTL6, accession number O94805)
Mouse: 98% identity (75/76 amino acids identical)
Rat: 98% identity (75/76 amino acids identical)
>50% identity with BAF53a

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N332B/15

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with BAF53a

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

ACTL6B

Official Name

ACTL6B

Full Name

BAF53b

Alternative Names

ACTL6B; ACTL6; BAF53B; arpNalpha; actin like 6B; EIEE76; IDDSSAD

Uniprot ID

O94805

Product Pictures

Fig. 1 Tissue and transfected cell immunoblot: extracts of rat brain low speed pellet (RBLSP) and COS cells transiently transfected with untagged BAF53a, BAF53b or Kv2.1 plasmids and probed with N332B/15 (left) and N52A/42 (right) TC supe.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Immunoblot versus samples from adult rat brain (RBLSP) and WT and BAF53b KO mouse brains probed with N332B/15 (left) and N336B/83 (right) TC supes.

Publications