NeuroMab™ Anti-FGFR3 BBB Shuttle Antibody(NRZP-1022-ZP3904)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

FGFR3

Official Name

FGFR3

Full Name

Fibroblast Growth Factor Receptor 3

Alternative Names

Fibroblast Growth Factor Receptor 3; EC 2.7.10.1; FGFR-3; JTK4; Fibroblast Growth Factor Receptor 3 Variant 4; Achondroplasia; Thanatophoric Dwarfism; Hydroxyaryl-Protein Kinase; Tyrosine Kinase JTK4;

Product Pictures

FuncS

Figure 1 shows the localization of 125 I-labeled MSPR059 in FDCP-FR3ach-derived tumors.

FuncS

Figure 2 shows the effect of MSPR059 on inhibiting ligand-independent tumor growth after 24 and 26 days.

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Figure 3 shows the effect of MSPR059 in inhibiting ligand-independent tumor growth.

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Figure 4 shows the effect of MSPR059 in inhibiting ligand-independent tumor growth.

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Figure 5 shows that scFv MSPRO59 blocks the proliferation of FDCP-FR3(S375C) cells.

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Figure 6 shows the effect of MSPR059 single chain antibody on the inhibition of ligand-independent tumor growth.

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Figure 7B shows that MSPRO12 and MSPR059 inhibit ligand-independent proliferation of FDCP-FR3ach cells. Panel A shows the analysis of ligand-dependent FDCP-FR3wt cells.