NeuroMab™ Anti-FGFR3 BBB Shuttle Antibody(NRZP-1022-ZP3905)
[CAT#: NRZP-1022-ZP3905]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- Block; Inhib; In Vitro; In Vivo
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SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
Block; Inhib; In Vitro; In Vivo
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
FGFR3
Official Name
FGFR3
Full Name
Fibroblast Growth Factor Receptor 3
Alternative Names
Fibroblast Growth Factor Receptor 3; EC 2.7.10.1; FGFR-3; JTK4; Fibroblast Growth Factor Receptor 3 Variant 4; Achondroplasia; Thanatophoric Dwarfism; Hydroxyaryl-Protein Kinase; Tyrosine Kinase JTK4;
Product Pictures
Neut
Figure 2 shows that FGFR3 neutralizing Fabs recognize IgII or IgII and III in the extracellular domain of FGFR3.
ELISA
Figure 3 shows that MSPR029 specifically recognizes the IIIc isoform of FGFR3.
FuncS
Figure 4 shows the results of a proliferation assay of FDCP-FR3IIIb or FDCP-FR3IIIc cells incubated with increasing doses of the indicated Fabs.
FuncS
Figure 5 shows the binding of iodinated MSPRO29 to FGFR3.
FuncS
Figure 6 AF shows selective binding of radiolabeled MS-PR029 to growth plate histology.
FuncS
Figure 7 shows the proliferation assay of FDCP-FR3 (C10) and FDCP-FR3ach cells incubated with FGF9 and increasing doses of the indicated Fabs.
FuncS
Figure 8 shows the recovery of RCS cell growth by MS-PROS4 and MSPRO59.
FuncS
Figure 9 shows the growth rate of bone treated with MS-PRO59.
FuncS
Figure 10 shows the results of a proliferation assay in which iodinated MSPRO29 retained its activity against FGFR3.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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