NeuroMab™ Anti-Gephyrin BBB Shuttle Antibody, Clone L106/4

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Gephyrin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-181 (N-terminus) of human Gephyrin (also known as Molybdopterin molybdenum transferase, MPT Mo-transferase, Domain G, Domain E, Putative glycine receptor-tubulin linker protein, GPHN, GPH and KIAA1385, accession number Q9NQX3) Mouse: 100% identity (181/181 amino acids identical)
Rat: 100% identity (181/181 amino acids identical) with isoform 5, slightly lower with other isoforms

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

L106/4

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Gephyrin

Official Name

GPHN

Full Name

Gephyrin

Alternative Names

GPHN; GEPH; GPH; GPHRYN; HKPX1; MOCODC; gephyrin

Uniprot ID

Q9NQX3

Product Pictures

Fig. 1 Array tomography immunofluorescence of an LRWhite-embedded 70 nm section from adult mouse cortex with L106/4 (green), rabbit mAb GAD2 (Cell Signaling #5843, magenta) and DAPI (blue). The insert shows three consecutive sections through the synapse that is marked with a white box.