NeuroMab™ Anti-LILRB2 BBB Shuttle Antibody(NRZP-1022-ZP2473)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; FC; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

LILRB2

Full Name

LILRB

Alternative Names

LILRB2; ILT4; MIR10; LIR2; MIR-10; LIR-2; leukocyte immunoglobulin like receptor B2; ILT-4; CD85D

Product Pictures

FCM

Fig.1 shows T cell proliferation in a Mixed Lymphocyte Reaction (MLR) setting.

ELISA

Fig.2 shows IFN γ production in a bidirectional Mixed Lymphocyte Reaction (MLR) setting by exemplary anti-LILRB 2 antibodies 13h1.g2 and 6g6.h7 and pan-anti-LILRB 1/2/3 antibody 9c9.e 6.

Both C320-168 and C320-179 bound the longer (72-251) and shorter (84-251) isoforms of soluble, cleaved TL1a.