NeuroMab™ Anti-Nav1.7 BBB Shuttle Antibody(NRZP-1022-ZP2490)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Pain; Epilepsy

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

SCN9A

Official Name

SCN9A

Full Name

sodium voltage-gated channel alpha subunit 9

Alternative Names

SCN9A; ETHA; FEB3B; GEFSP7; HSAN2D; NE-NA; NENA; Nav1.7; PN1; SFNP; sodium voltage-gated channel alpha subunit 9

Product Pictures

ELISA

Fig.1 shows ELISA responses of 1E16 mAb and 115 mAb using intact Nav1.7 DII VSD. Data are shown as means S.E.M (n=3).

Representative traces and current¨voltage relationship from HEK293 cells expressing human Nav1.7 channels (A), in the presence of 1E16 (100 nM) and the peptide (1 ilM) (B), and after washout in the presence of 1E16 (100 nM) only (C).

ELISA

Fig.2 shows that 1E16 reduced inflammatory and neuropathic pain and suppressed spinal cord synaptic transmission in mice.

Time course of licking and flinching behavior following intraplantar injection of 5% formalin.

ELISA

Fig.3 shows the effect of the mAb on persistent sodium currents (INaPs) in small-sized neurons of whole mount dorsal root ganglions (DRGs) from naïve mice and mice with nerve injury (CCI.).

Time course of licking and flinching behavior following intraplantar injection of 5% formalin.

ELISA

Fig.4 shows the binding of the 1E16 antibody to human Nav1.7. The data are shown as means S.E.M. (n=10).

Time course of licking and flinching behavior following intraplantar injection of 5% formalin.

ELISA

Fig.5 shows state (use)-dependent inhibition of human Na 1.7 by 1E16.

Plot of normalized current amplitudes during 30-ms depolarizing pulses to -10 mV applied from a holding potential of -120 mV at 0.1 (A), 2 (0), and 10 (o) Hz in the presence of 100 nM 1E16.

Publications