NeuroMab™ Anti-Navbeta3 Na+ channel BBB Shuttle Antibody, Clone N396/29

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN3B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-215 (full-length) of rat Navbeta3 (also known as Sodium channel subunit beta-3, Scn3b and KIAA1158, accession number Q9JK00)
Mouse: 99% identity (214/215 amino acids identical)
Human: 98% identity (211/215 amino acids identical)
<50% identity with Navbeta1, Navbeta2 or Navbeta4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N396/29

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Navbeta1, Navbeta2 or Navbeta4

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN3B

Official Name

SCN3B

Full Name

Navbeta3 Na+ channel

Alternative Names

Sodium Voltage-Gated Channel Beta Subunit 3; Sodium Channel; Voltage-Gated; Type III; Beta Subunit; Sodium Channel; Voltage Gated; Type III Beta Subunit; Sodium Channel; Voltage-Gated; Type III; Beta; Voltage-Gated Sodium Channel Beta-3 Subunit; Sodium Channel Subunit Beta-3;

Uniprot ID

Q9JK00

Product Pictures

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Navbeta1, V5/His-tagged Navbeta2, V5/His-tagged Navbeta3, GFP-tagged Navbeta4 or untagged Kv2.1 plasmid and probed with mouse N396/29 TC supes.

Fig. 2 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Navbeta1, V5/His-tagged Navbeta2, V5/His-tagged Navbeta3, GFP-tagged Navbeta4 or untagged Kv2.1 plasmid and probed with mouse anti-V5 TC supes.

Fig. 3 Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Navbeta1, V5/His-tagged Navbeta2, V5/His-tagged Navbeta3, GFP-tagged Navbeta4 or untagged Kv2.1 plasmid and probed with N52A/42 TC supes.