NeuroMab™ Anti-Notch1 BBB Shuttle Antibody(NRZP-1022-ZP3208)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

IHC; ELISA; In Vitro

Relevant Diseases

Alzheimer's Disease; Epilepsy; Pain

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Notch1

Official Name

notch 1

Full Name

notch 1

Alternative Names

AOVD1; Translocation-associated notch protein TAN-1; NEXT; hN1; AOS5; NICD; Notch 1; Neurogenic locus notch homolog protein 1; TAN1

Product Pictures

FuncS

Figure 1. Lactate dehydrogenase assay results from adenoid cystic carcinoma subjects treated with anti-Notch1 antibody OMP-52M51.

FuncS

Figure 2. Liver CT scans of subjects with adenoid cystic carcinoma before and after treatment with the anti-Notch1 antibody OMP-52M51.

FuncS

Figure 3. Notch1 signal detection.

IHC

Figure 4. Immunohistochemical detection of Notch1 ICD. Figure 4A. Positive control tumor OMP-B40. Figure 4B. Negative control tumor OMP-C11. Figure 4C. Tumors in ACC patients.

Publications