NeuroMab™ Anti-Notch1 BBB Shuttle Antibody(NRZP-1022-ZP3212)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Inhib; Block; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Epilepsy; Pain

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

Notch1

Official Name

notch 1

Full Name

notch 1

Alternative Names

AOVD1; Translocation-associated notch protein TAN-1; NEXT; hN1; AOS5; NICD; Notch 1; Neurogenic locus notch homolog protein 1; TAN1

Product Pictures

ELISA

Figure 1 is a histogram summarizing the results of experiments to determine the specificity of antibodies binding to human Notch 1 on the surface of CHO-Flpln-Notch 1 cells. Antibodies 2G10, 2E6 (also referred to herein as antibody 2E06), 2A11 and 2D11 are shown from left to right.

Publications