NeuroMab™ Anti-PICK1 scaffold BBB Shuttle Antibody, Clone L20/8

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-PICK1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 10-130 of human PICK1 (also known as Protein interacting with C kinase 1, Protein kinase C-alpha-binding protein, PRKCA-binding protein and Prkcabp, accession number Q9NRD5)
Rat: 100% identity (121/121 amino acids)
Mouse: 99% identity (120/121 amino acids)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

L20/8

Applications

WB; IHC; IP; ICC

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

PICK1

Official Name

PICK1

Full Name

PICK1

Alternative Names

Protein Interacting With PRKCA 1; Protein Kinase C-Alpha-Binding Protein; Protein Interacting With C Kinase 1; PRKCABP; Protein Kinase C; Alpha Binding Protein; Protein Interacting With PRKCA; PRKCA-Binding Protein; PICK;

Uniprot ID

Q9NRD5

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with L20/8 (left) or N52A/42 (right) TC supe.

Fig. 2 Adult rat brain membrane immunoblot.

IHC

Fig. 3 Adult rat hippocampus immunohistochemistry.

Fig. 4 Immunoblot against membrane fractions from adult rat brain (RBM) and hippocampi (MHM) from wild-type (WT) and PICK1 knockout (KO) mice probed with L20/8 TC supe.

Publications