NeuroMab™ Anti-Thorase (Atad1) BBB Shuttle Antibody, Clone N125/10

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Thorase BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-361 (full-length) of mouse Thorase (also known as ATPase family AAA domain-containing protein 1 and Atad1, accession number Q9D5T0)
Human: 100% identity (361/361 amino acids identical)
Rat: 99% identity (360/361 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N125/10

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Thorase

Official Name

ATAD1

Full Name

Thorase/Atad1

Alternative Names

AAA Domain Containing Protein 1

Uniprot ID

Q9D5T0

Product Pictures

Fig. 1 Immunoblots versus crude adult rat brain membranes (RBM) and brain extracts from Thorase WT and KO mice and probed with N125/10 (left) and N52A/42 (right) TC supe.

Fig. 2 Immunoblots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)], and cerebellum [HBM(Cb)].