NeuroMab™ Anti-VGAT BBB Shuttle Antibody, Clone L118/66 ure

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VGAT BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-133 (cytoplasmic N-terminus) of mouse VGAT (also known as GABA and glycine transporter, Vesicular inhibitory amino acid transporter, Vesicular GABA transporter, Solute carrier family 32 member 1, VIAAT and SLC32A1, accession number O35633)
Rat: 99% identity (132/133 amino acids identical)
Human: 96% identity (128/134 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

VGAT

Official Name

VGAT

Alternative Names

vesicular GABA transporter

Product Pictures

IHC

Fig. 1 Adult rat brain cortex immunohistochemistry.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Array tomography immunofluorescence of a single 70 nm section (left) and volume reconstruction of 8 serial sections (right) of LRWhite-embedded adult mouse cerebellum with L118/66 (VGAT, green), rabbit mAb GAD2 and DAPI (blue). Purkinje cells (PC) have a low level of VGAT immunoreactivity, and numerous inhibitory synaptic varicosities in molecular (M) and granule (G) layers are colabeled with VGAT and GAD2.