NeuroMab™ Rat Anti-TAC1 Monoclonal Antibody (CBP1519)

[CAT#: NAB2007FY333]

Rat Monoclonal [NC1/34] to TAC1

Host Species:: Rat

Species Reactivity:: Mammals; Porcine; Porcineeon; Bichir; Rabbit; Human; Bovine; Guinea Porcine; Calanus sp.; Crustacea; Cancer sp.; Panilurus sp.; Homarus sp.; Mudpuppy; Lamprey; Crayfish; Zebrafish; Bullfrog; Amphibia; Cockroach; Sheep; Cowbird; Rat; Spadefoot toad; Chicken; Chinchilla; Camel; Beaver

Applications:: IF; IHC-Fr; IHC-P

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Product Overview

Description

Rat anti-substance P antibody, clone NC1 / 34 recognizes the COOH end of substance P. P OH is a short peptide neurotransmitter that regulates the excitability of nociceptive neurons in the dorsal horn. It is known to play a role in various physiological activities, such as pain transmission, vomiting reflex, saliva secretion and smooth muscle contraction.
The reactivity of eledoisin is 5%. It does not react with Leu or Met-enkephalin, somatostatin or β-endorphin.

Immunogen

Substance P conjugated to Bovine Serum Albumin.

Species Reactivity

Mammals; Porcine; Porcineeon; Bichir; Rabbit; Human; Bovine; Guinea Porcine; Calanus sp.; Crustacea; Cancer sp.; Panilurus sp.; Homarus sp.; Mudpuppy; Lamprey; Crayfish; Zebrafish; Bullfrog; Amphibia; Cockroach; Sheep; Cowbird; Rat; Spadefoot toad; Chicken; Chinchilla; Camel; Beaver

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a

Clone Number

CBP1519

Applications

IF; IHC-Fr; IHC-P

Application Notes

IHC-P (1/100-1/200); IHC-Fr (1/100-1/200)

Research Areas

Growth and Development

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1334

Product Properties

Form

Liquid

Formulation

Tissue Culture Supernatant-liquid
0.05% Thiomersal

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Target

Neurokinin A

Official Name

TAC1

Full Name

TAC1 tachykinin, precursor 1

Alternative Names

TAC2; NKNA; Neurokinin A

Gene ID

6863(Human); 21333(Mouse); 24806(Rat)

Uniprot ID

P20366(Human); P41539(Mouse); P06767(Rat)

References

1. Cuello, A.C. et al. (1979) Detection of substance P in the central nervous system by a monoclonal antibody.
2. Czujkowska, H. & Arciszewski, M.B. (2011) Expression of corticotropin releasing factor (CRF) in the enteric nervous system of the jejunum of sheep
3. Kato, A. et al. (2012) Endocannabinoid-dependent plasticity at spinal nociceptor synapses.
4. Arciszewski, M.B. et al. (2009) Expression of vasoactive intestinal polypeptide, substance P and neuropeptide Y in jejunal enteric nerves is altered in rabbits suffering from long term Trichinella spiralis infection: an immunohistochemical study

Publications