NeuroMab™ Mouse Anti-Human MERTK Monoclonal Antibody (CBP2232)

Product Overview

Description

MERTK plays a role in the retinal pigment epithelium as a regulator of rod outer segments fragments phagocytosis. MERTK also plays a role in the inhibition of Toll-like receptor-mediated innate immune responses through the activation of STAT1. Upregulation of MERTK seems to also promote the survival of certain cancer cells, such as t(1;19)-positive acute lymphoblastic leukemias (ALL). MERTK also has a role in cellular migration, as MERTK KO macrophages demonstrate cytoskeletal disruptions that impacts its shape and directional migration. Melanoma cells express high levels of MERTK, which makes this molecule an attractive therapeutic target.

Immunogen

MERTK extracellular domain/Fc fusion.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP2232

Applications

Application Notes

FCM (5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1657

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MERTK

Official Name

MERTK

Full Name

MER Proto-Oncogene, Tyrosine Kinase

Alternative Names

MER Proto-Oncogene; Tyrosine Kinase

Gene ID

10461(Human)

Uniprot ID

Q12866(Human)

References

1. Schlegel J, et al. 2013. J. Clin. Invest. 123:2257.
2. Chen J, et al. 1997. Oncogene 14:2033.
3. Yefimova MG, et al. 2013. Autophagy 9:653.
4. Zhang W, et al. 2013. J. Med. Chem. 56:9693.
5. Lee YJ, et al. 2012. J. Leuko. Biol. 91:921.
6. Krause S, et al. 2015. Blood 125:820.
7. Tang Y, et al. 2015. PLoS One 10:e0117787.

Publications