Mouse Anti-Human MERTK Monoclonal Antibody (CBP2274)

Product Overview

Description

MERTK is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family, which preferentially is expressed by macrophages, dendritic cells, and natural killer cells. It plays an important role in processes such as macrophage activation, apoptotic cell engulfment, platelet aggregation, and clot stability. MERTK can be activated by dimerization and autophosphorylation through ligand binding or homophilic cell-cell interaction mediated by its NCAM-like motif. The downstream signaling components include PI3 kinase, PLCγ, and MAP kinase. MERTK is upregulated in a wide variety of cancers including leukemia, non-small cell lung cancer, glioblastoma, melanoma, prostate cancer, breast cancer, colon cancer, and gastric cancer.

Immunogen

Extracellular domain of recombinant partial-length human MERTK.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2274

Applications

Application Notes

WB (1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MERTK

Official Name

MERTK

Full Name

MER Proto-Oncogene, Tyrosine Kinase

Alternative Names

MER Proto-Oncogene; Tyrosine Kinase

Gene ID

10461(Human)

Uniprot ID

Q12866(Human)

References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. TroWBridge IS, et al. 1993. Annu. Rev. Immunol. 12:85.
3. Kishihara K, et al. 1993. Cell 74:143.
4. Pulido R, et al. 1988. J. Immunol. 140:3851.

Publications