NeuroMab™ Mouse Anti-Rat TOMM40 Monoclonal Antibody (CBP2261)

Product Overview

Description

Mitochondria fulfill central functions in cellular energetics, metabolism, and signaling. The outer membrane translocator complex (the TOM complex) imports most mitochondrial proteins, and TOMM40 is the key subunit of the complex, the pore through which the vast majority of imported proteins must pass. TOMM40 possesses chaperone-like properties, which helps expedite movement of the pre-proteins through the channel. TOM cooperates with the TIM23 (Translocase of the Inner Membrane 23) complexes to import matrix-targeted proteins. TOMM40 is implicated in many neurodegenerative diseases; reduced TOMM40 mRNA expression in Alzheimer's disease patients was shown to correlate with cognitive decline.

Immunogen

A synthetic peptide corresponding to TOMM40 protein.

Species Reactivity

Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP2261

Applications

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1674

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

TOMM40

Official Name

TOMM40

Full Name

Mitochondrial import receptor subunit TOM40 homolog

Alternative Names

Mitochondrial import receptor subunit TOM40 homolog

References

1. Gottschalk WK, et al. 2014. J. Parkinsons Dis. Alzheimers Dis. 12.
2. Shiota T, et al. 2015. Science 349:1544-8.
3. Mise A, et al. 2017. J. Alzheimers Dis. 60:1107-1117.
4. Ahting U, et al. 2001. J. Cell. Biol. 153:1151-60.

Publications