NeuroMab™ Mouse Anti-Porin Monoclonal Antibody (CBP2341)

[CAT#: NAB2010328LS]

Anti-Porin Monoclonal Antibody [Alexa Fluor 647]

Host Species:: Mouse

Species Reactivity:: Vertebrate; Xenopus; Yeast

Applications:: ICC; FC

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Product Overview

Description

Nuclear pores are large protein complexes that cross the nuclear envelope. The proteins that make up the nuclear pore complex are known as nucleoporins. About half of the nucleoporins typically contain solenoid protein domains-either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. Each NPC contains at least 456 individual protein molecules and is composed of 30 distinct proteins (nucleoporins). The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered secondary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine-glycine repeats.

Immunogen

The antibody was raised using a nuclear pore complex mixture.

Species Reactivity

Vertebrate; Xenopus; Yeast

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2341

Applications

ICC; FC

Application Notes

ICC (0.5-2.0 μg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1728

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Porin

Official Name

Porin

Full Name

Porin

Alternative Names

107 kD nucleoporin; NPC proteins; Nuclear pore complex protein Nup107; Nucleoporin 107kD; Nucleoporin Nup107; NUP 107; NUP 84; NUP107; NUP153; NUP155; NUP84; NUP98

Publications