NeuroMab™ Mouse Anti-HSP60 Monoclonal Antibody (CBP2400)

Product Overview

Description

HSP60, a mitochondrial chaperonin, is essential for the refolding, assembly, and transportation from the cytoplasm to mitochondrial matrix. It shares a high degree of homology and function similarity to bacteria GroEL. Studies also show that HSP60 may participate in some autoimmune diseases along with autosomal dominant and autosomal recessive neurodegenerative disorders.

Immunogen

Purified recombinant fragment (265-462 a.a.) of human HSP60 expressed in E. coli.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2400

Applications

Application Notes

WB (1:1000-1:2000)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1765

Product Properties

Form

Liquid

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Handling Advice

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

HSP60

Official Name

HSP60

Full Name

Heat shock protein 60

Alternative Names

HSPD1; HLD4; CPN60; GROEL; HSP65; SPG13; HuCHA60; Mitochondrial Matrix Protein P1; P60 Lymphocyte Protein

References

1. Bukau B, Horwich AL. 1998. Cell 92:351.
2. Hansen JJ, et al. 2002. Am. J. Hum. Genet. 70:1328.
3. Kol A, et al. 2000. J. Immunol. 164:13.
4. Jindal S, et al. 1989. Mol. Cell Biol. 9:2279.
5. Magen D, et al. 2008. Am. J. Hum. Genet. 83:30.
6. Chandra D, et al. 2007. J. Biol. Chem. 282:31289.

Publications