NeuroMab™ Mouse Anti-CD36 Monoclonal Antibody (CBP2582)

Product Overview

Description

Rat anti-Mouse CD36 antibody, recognizes mouse CD36, also known as platelet glycoprotein 4, glycoprotein IIIb or PAS IV. CD36 is a ~85 kDa transmembrane glycoprotein, which is mainly expressed on platelets, monocytes/macrophages, smooth muscle and endothelial cells. The CD36 molecule is a B-type scavenger receptor that can bind to a variety of ligands, including thrombospondin, anionic phospholipids, oxidized low-density lipoproteins and long-chain fatty acids. CD36 has multiple functions and is reported to play a role in innate immunity, platelet adhesion/aggregation and long-chain fatty acid transport. CD36 molecules also directly mediate the cell adhesion of red blood cells infected by Plasmodium falciparum, and may participate in the development of atherosclerotic lesions and the formation of foam cells.

Immunogen

Peritoneal macrophages induced by thioglycolate in mice treated with IL-4.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2582

Applications

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1878

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.05 mg/ml

Purification

Protein G

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD36

Official Name

CD36

Full Name

CD36 Molecule

Alternative Names

CD36 Molecule; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor); CD36 Molecule (Thrombospondin Receptor); Leukocyte Differentiation Antigen CD36; Platelet Glycoprotein IV; Fatty Acid Translocase; Glycoprotein IIIb; PAS IV; GPIIIB; GP3B; GPIV; FAT; GP4;

Gene ID

948(Human); 12491(Mouse); 29184(Rat)

Uniprot ID

P16671(Human); Q08857(Mouse); Q07969(Rat)

References

1. Mwaikambo, B.R. et al. (2009) Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms.
2. Yang, C.N. et al. (2011) Mechanism mediating oligomeric Aβ clearance by naïve primary microglia.
3. Seeds, R.E. et al. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.
4. Samovski, D. et al. (2012) Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.
5. Zhou, D. et al. (2012) CD36 level and trafficking are determinants of lipolysis in adipocytes.

Publications