NeuroMab™ Mouse Anti-CD36 Monoclonal Antibody (CBP2581)

Product Overview

Description

Mouse anti-human CD36 antibody, recognizes CD36 antigen, a cell surface glycoprotein of approximately 88 kDa, expressed by platelets, monocytes/macrophages, and some microvascular endothelial and erythroid precursors. CD36 is the receptor for thrombospondin. When expressed by monocytes and macrophages, CD36 acts as a receptor for oxidized LDL and apoptotic polymorphonuclear cells. Mouse anti-human CD36 antibody, clone SMØ, partially inhibits collagen-induced platelet aggregation and macrophages uptake of apoptotic neutrophils. According to reports, this antibody can activate platelets through fibrinogen binding, P-selectin expression and annexin V binding-for more details, please contact our technical service team.

Immunogen

Human tonsil cells and peripheral blood mononuclear cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgM

Clone Number

CBP2581

Applications

Application Notes

FC: 1/5-1/10

Relevant Diseases

Alzheimer's Disease; Neurodegenerative Disease

Research Areas

Neuroregeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1877

Product Properties

Form

Liquid

Formulation

PBS, 0.09% Sodium Azide, 1% BSA

Preservatives

YES

Concentration

0.05 mg/ml

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend micr°Centrifugation before use.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD36

Official Name

CD36

Full Name

CD36 Molecule

Alternative Names

CD36 Molecule; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor); CD36 Molecule (Thrombospondin Receptor); Leukocyte Differentiation Antigen CD36; Platelet Glycoprotein IV; Fatty Acid Translocase; Glycoprotein IIIb; PAS IV; GPIIIB; GP3B; GPIV; FAT; GP4;

Gene ID

948(Human); 12491(Mouse); 29184(Rat)

Uniprot ID

P16671(Human); Q08857(Mouse); Q07969(Rat)

References

1. Sarigianni, M. et al. (2010) Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy participants.
2. Sugihara, K. et al. (1992) Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells.
3. Biswas, A.K. et al. (2007) Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping.
4. Pain, A. et al. (2001) Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria.

Publications