Mouse Anti-MYOC Monoclonal Antibody (CBP2677)

[CAT#: NAB20101751CR]

Mouse Monoclonal (4B1F6) to MYOC

Host Species:: Mouse

Species Reactivity:: Human; Mouse; Porcine; Rat

Applications:: IHC; WB; ELISA

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Product Overview

Description

Myocilin (MYOC) is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina (PMID: 9176893; 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) (PMID: 21709622).

Expression Host

Mammalian cells

Immunogen

Myocilin fusion protein Ag5492

Species Reactivity

Human; Mouse; Porcine; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2677

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Myocilin

Official Name

MYOC

Full Name

Myocilin, trabecular meshwork inducible glucocorticoid response

Alternative Names

GLC1A; GPOA; JOAG; JOAG1; MYOC; myocilin; TIGR

Gene ID

4653(Human); 17926(Mouse); 81523(Rat)

Uniprot ID

Q99972(Human); O70624(Mouse); Q9R1J4(Rat)

References

1. Hara, S., Tsujikawa, M., & Nishida, K. (2019). Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells. Biochemical and biophysical research communications, 514(3), 580-585.

Publications