Product
Anti-CD45RO Monoclonal Antibody (CBP3669)
[CAT#: NAB2012810LS]
Anti-CD45RO Monoclonal Antibody [Alexa Fluor 594 ]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Chimpanzee; Cynomolgus; Common Marmoset
- Applications:
- IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
CD45RO is a 180 kD single chain membrane glycoprotein. Cd45RO is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22.
Immunogen
IL-2 dependent T cell line, CA1
Species Reactivity
Human; Chimpanzee; Cynomolgus; Common Marmoset
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG2a, κ
Clone Number
CBP3669
Applications
IHC-P
Application Notes
IHC-P (5.0-10 μg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
CD45RO
Official Name
CD45RO
Full Name
Protein tyrosine phosphatase
Alternative Names
MBP
References
1. Yi JJ, et al. 2010. Cell 142:144.
2. Tran DQ, et al. 2009. Blood 113:5125.
3. Lu M, et al. 2002. J. Cell. Sci. 115:4641.
4. Khalil N. 1999. Microbes Infect. 1:1255.
2. Tran DQ, et al. 2009. Blood 113:5125.
3. Lu M, et al. 2002. J. Cell. Sci. 115:4641.
4. Khalil N. 1999. Microbes Infect. 1:1255.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
