NeuroMab™ Anti-CD45RO BBB Shuttle Antibody(NRZP-1022-ZP2756)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Mouse; Humanized

Applications

FC; ELISA; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

CD45RO

Official Name

CD45RO

Product Pictures

FuncS

Figure 1 shows the magnetic isolation of CD45R0-expressing cells from PBMCs using the Fab variants "muCD45R0" and "huCD45R0_v3".

FCM

Figure 2 shows flow cytometric analysis of human PBMCs stained with Fab variants "muCD45R0" and "huCD45R0_v1".

Purified Fabs against CD45R0 were used in combination with an anti-His-PE conjugate for an indirect staining of human PBMC. The mean fluorescence intensity (MFI) of anti-His-PE is plotted against the Fab concentration.