Rat Anti-Galectin-7 Monoclonal Antibody (CBP4300)

Product Overview

Description

The galectins are a family of beta-galactoside-binding proteins implicated in cell-cell and cell-matrix interactions. Galectin-7 is specifically expressed in stratified epithelia and epidermis, but barely detected in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 is a p53-induced protein and is abnormally expressed in variety of tumors such as melanoma, lung cancer and colon cancer. In UVB-induced sunburn keratinocytes, the expression of Galectin-7 is markedly increased due to the genotoxic stress-induced p53 activation. Both positive and negative regulatory roles of Galectin-7 have been reported in tumorigenesis.

Immunogen

Recombinant human Galectin-7

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP4300

Applications

IHC-P

Application Notes

IHC-P (0.5-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 488

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Galectin 7

Official Name

LGALS7

Full Name

Galectin-7

Alternative Names

LGALS7; GAL7; LGALS7A; galectin 7

Gene ID

3458

Uniprot ID

P47929(Human); O54974(Mouse); P97590(Rat)

References

1. Bernerd F. et al. 1999. Proc Natl Acad Sci U S A. 96(20):11329-34.
2. Madsen P. et al. 1995. J Biol Chem. 270(11):5823-9.
3. Biron-Pain K. et al. 2013. PLoS One. 8(5):e63307.

Publications