NeuroMab™ Mouse Anti-Human Gemin 4 Monoclonal Antibody (CBP4308)

Product Overview

Description

Gemin 4 is one of the core components of the survival of motor neurons (SMNs) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. Recent studies have shown that one of the three putative nuclear localization signal motifs in Gemin 4 is necessary and sufficient to direct the nuclear import of the other two SMN complex components, Gemin 2 and Gemin 3. This suggests that Gemin 4 plays an essential role in mammalian snRNP biogenesis via facilitating the import of the SMN complex or subunits into the nucleus.

Immunogen

Histidine-tagged recombinant protein corresponding to human Gemin 4

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4308

Applications

Application Notes

WB (0.5-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2306

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

GEMIN4

Official Name

GEMIN4

Full Name

Gem (nuclear organelle) associated protein 4

Alternative Names

GEMIN4; Gem (nuclear organelle) associated protein 4

Gene ID

50628(Human)

Uniprot ID

Q8WUM5(Human)

References

1. Meier ID, et al. 2018. Biol Open. 7(2)
2. Battle DJ, et al. 2007. J Biol Chem. 282(38):27953
3. Wang JL, et al. 2004. Biochim Biophys Acta. 1673(1-2):75.

Publications