Human CHO-K1/DP1/Gα15 Stable Cell Line

[CAT#: NCL20120121CR]

Prostanoid Receptor DP1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Request Pricing

Inquiry

Product Overview

Description

It binds to PGD2 and PGE2. DP1 can inhibit platelet aggregation, and also inhibit leukotriene B4 and superoxide anion (O2-) release from human neutrophils. It can relax smooth muscle and regulate eosinophil apoptosis. DP receptor knockout OVA-challenged mice exhibit reduced Th2 cytokine levels and lymphocyte accumulation in the lung. In addition, they failed to produce asthmatic responses.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Stem Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

PTGDR/DP1

Family

Prostanoid receptor

Strain

DP1/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

PTGDR

Official Name

PTGDR

Alternative Names

DP1 receptor; prostaglandin D; DP; DP1; PTGDR1; Ptgdr; Ptgdr2; Ptgdrl; PGD receptor-like; PGD2 receptor-like; prostaglandin D receptor; prostaglandin D receptor-like; prostaglandin D2 receptor; prostaglandin D2 receptor-like; prostanoid DP receptor-like

Gene ID

5729(Human); 19214(Mouse); 498475(Rat)

Uniprot ID

Q13258(Human); P70263(Mouse); Q9R261(Rat)

References

1. Li, T., Ju, E., & Gao, S. J. (2019). Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis. The Journal of clinical investigation, 129(8). 2. Huang, X., Zhang, Q., Lou, Y., Wang, J., Zhao, X., Wang, L.,.. & Liang, T. (2019). USP22 deubiquitinates CD274 to suppress anticancer immunity. Cancer immunology research, 7(10), 1580-1590. 3. Cheng, Z., Zhang, X., Huang, P., Huang, G., Zhu, J., Chen, F.,.. & Wang, X. (2020). Nup96 and HOS1 are mutually stabilized and gate CONSTANS protein level, conferring long-day photoperiodic flowering regulation in Arabidopsis. The Plant Cell, 32(2), 374-391.

Publications