Human CHO-K1/GNRHR/Gα15 Stable Cell Line

[CAT#: NCL20120070CR]

Gonadotropin-releasing Hormone Receptor Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

The gonadotropin-releasing hormone receptor (GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Evidence exists showing the presence of LHRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

Ham's F12, 10% FBS, 400 μg/ml G418, 100 μg/ml Hygromycin B

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

GNRHR

Family

Gonadotropin releasing hormone receptor

Strain

GNRHR/Gα15 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

GnRHR

Official Name

GNRHR

Alternative Names

GnRH receptor; luteinizing hormone-releasing hormone (LHRH) receptor; LHRHR; LRHR; GRHR; GNRHR1; luliberin receptor; GnRH1; Type I GnRHR; LHRH receptor; GnRH I receptor; GH1; gnRH receptor; gnRH-R; gonadotropin-releasing hormone receptor; growth hormone

Gene ID

2798(Human); 14715(Mouse); 81668(Rat)

Uniprot ID

P30968(Human); Q01776(Mouse); P30969(Rat)

References

1. Zhang, W., Chen, L., Ma, Z., Du, L., & Li, M. (2014). Design, synthesis and biological evaluation of naphthalimidebased fluorescent probes for α1-adrenergic receptors. Drug Discoveries & Therapeutics, 8(1), 11-17.

Publications