Human HEK293/MCH1 Stable Cell Line

[CAT#: NCL20120082CR]

Melanin-concentrating Hormone Receptor 1 Stable Cell Line

Species:: Human

Applications:: GPCR Screening

Cell Types:: Other Cells

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Product Overview

Description

It is an integral plasma membrane protein that binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Melanin-concentrating hormone (MCH) is an important neuropeptide hormone involved in multiple physiological processes. Peptide derivatives of MCH have been developed as tools to aid researches that involve potent radioligands, receptor selective agonists, and potent antagonists. These tools have been used to further understand the role of MCH's physiology primarily in rodents.

Cell Types

Other Cells

Applications

GPCR Screening

Research Areas

GPCR; Neural Cell

Species

Human

Properties

Size

>1x10^6 Cells

Form

Frozen cells

Culture Medium

DMEM, 10% FBS, 200 μg/ml Zeocin

Freeze Medium

45% culture medium, 45% FBS, 10% DMSO

Receptor

MCH1/GPR24

Family

Melanin concentrating hormone receptor

Strain

MCH1 Cell Line

Cell Purity

>95%

Shipping

Dry ice

Storage

Liquid nitrogen immediately upon delivery

Handling Advice

Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Warnings

Store under recommended storage conditions (liquid nitrogen). Do not expose to high temperature. After expiration, discard all remaining reagents.

Target Details

Target

MCH1

Official Name

MCH1

Alternative Names

MCH1 receptor; SLC1; MCHR1; MCH-1R; gpr 24; SLC-1; GPR24; MCH1R; G protein-coupled receptor 24; MCH receptor 1; MCH-R1; MCHR; MCHR-1; melanin-concentrating hormone receptor 1; somatostatin receptor-like protein; Gpr24-9; AW049955

Gene ID

4170(Human); 17210(Mouse); 60430(Rat)

Uniprot ID

Q07820(Human); P97287(Mouse); Q9Z1P3(Rat)

References

1. Ghosh, E., Dwivedi, H., Baidya, M., Srivastava, A., Kumari, P., Stepniewski, T.,.. & Roy, D. (2019). Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms. Cell reports, 28(13), 3287-3299. 2. Hernandez-Gordillo, V., & Chmielewski, J. (2014). Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds. Biomaterials, 35(26), 7363-7373.

Publications