Creative Biolabs

iNeu DopaNeurons PD SNCA A53T HZ Kit, Disease Model

[CAT#: NCL-7P026]

DopaNeurons Parkinson's Disease differentiated from Human iPS cells, frozen

Species:
Human
Applications:
Cell Assay
Cell Types:
DopaNeuron

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Description
SNCA A53T is one of the most permeable and widely studied mutations associated with Parkinson's disease (PD). SNCA encodes the alpha-synuclein (α-syn) protein, which is mainly expressed at the presynaptic terminal of the brain The A53T mutation makes α-syn more likely to accumulate and accumulate, which is a hallmark indicator of PD pathology.

In order to generate heterozygous (HZ) A53T allelic variants that are syngeneic to iNeu® DopaNeurons, nuclease-mediated SNP changes were performed on healthy control iPS cell lines to introduce this site-specific mutation into the SNCA gene. Then, this genome-engineered iPS cell differentiates into Human midbrain floor plate dopaminergic (DA) neurons to produce iNeu DopaNeurons SNCA A53T HZ.
Features
Easy to implement
iNeu DopaNeurons are shipped cryopreserved with optimized media. Simply thaw and use.

Homogenous and reproducible
iNeu DopaNeurons are fully differentiated neurons, not precursors, providing biologically relevant and reproducible results.

Highly pure
iNeu DopaNeurons are>80% tyrosine hydroxylase positive (THpos) midbrain dopaminergic neurons, enabling mechanistic studies of neurodegenerative diseases.

Human cells
iNeu DopaNeurons are floor plate-derived dopaminergic neurons from Human iPS cells ensuring complete regional specification for full functionality.
Cell Types
DopaNeuron
Applications
Cell Assay
Species
Human
Size
1 Vial: ≥ 1 x 10^6 cells/vial
Components
Cryopreserved MyCell DopaNeurons SNCA A53T HZ, 01279
100 ml iNeu Neural Base Medium 1
2 ml iNeu Neural Supplement B
1 ml iNeu Nervous System Supplement
Tissue Source
Fibroblast
Age
<18
Mycoplasma Testing
The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.
Shipping
Dry ice.
Storage
Liquid Nitrogen
Research Use Only
For research use only
Quality Control
All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Target
ASIC1
Official Name
ASIC1
Alternative Names
ASIC1; ACCN2; ASIC; BNaC2; Acid sensing ion channel subunit 1
Gender
Female
Donor Health
Healthy
Ethnicity
Caucasian

For Research Use Only. Not For Clinical Use.
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