iNeu™ DopaNeurons PD SNCA A53T HZ, Disease Model

[CAT#: NCL-7P027]

DopaNeurons Parkinson's Disease differentiated from Human iPS cells, frozen

Species:: Human

Cell Types:: Dopaminergic Neurons

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Product Overview

Description

SNCA A53T is one of the most permeable and widely studied mutations associated with Parkinson's disease (PD). SNCA encodes the alpha-synuclein (α-syn) protein, which is mainly expressed at the presynaptic terminal of the brain The A53T mutation makes α-syn more likely to accumulate and accumulate, which is a hallmark indicator of PD pathology.

In order to generate heterozygous (HZ) A53T allelic variants that are syngeneic to iNeu® DopaNeurons, nuclease-mediated SNP changes were performed on healthy control iPS cell lines to introduce this site-specific mutation into the SNCA gene. Then, this genome-engineered iPS cell differentiates into Human midbrain floor plate dopaminergic (DA) neurons to produce iNeu DopaNeurons SNCA A53T HZ.

Features

Easy to implement
iNeu DopaNeurons are shipped cryopreserved with optimized media. Simply thaw and use.

Homogenous and reproducible
iNeu DopaNeurons are fully differentiated neurons, not precursors, providing biologically relevant and reproducible results.

Highly pure
iNeu DopaNeurons are>80% tyrosine hydroxylase positive (THpos) midbrain dopaminergic neurons, enabling mechanistic studies of neurodegenerative diseases.

Human cells
iNeu DopaNeurons are floor plate-derived dopaminergic neurons from Human iPS cells ensuring complete regional specification for full functionality.

Neurological Disease Models

PD-related Cells

Cell Types

Dopaminergic Neurons

Relevant Diseases

Parkinson's Disease

Species

Human

Properties

Size

1 Vial: ≥ 1 x 10^6 cells/vial

Tissue Source

Fibroblast

Age

<18

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Target Details

Target

SNCA

Official Name

ASIC2

Alternative Names

Acid Sensing Ion Channel Subunit 2; Amiloride-Sensitive Cation Channel 1; Neuronal; Mammalian Degenerin Homolog; Brain Sodium Channel 1; ACCN1; BNaC1; ACCN; BNC1; MDEG; Neuronal Amiloride-Sensitive Cation Channel 1;

Donor Information