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Creative Biolabs
Product

iNeu™ GABANeurons

[CAT#: NCL-7P023]

GABANeurons differentiated from Human iPS cells, frozen

Species:
Human
Cell Types:
GABANeuron

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Product Overview

Description

Traditional neuroscience research tools are mainly composed of rodent primary cell cultures and animal models. These are labor-intensive, costly, and cannot well reflect local Human biology. iNeu® GABANeurons represents a A related Human in vitro system used to model and interrogate complex neural processes and diseases.

iNeu GABANeurons is a mixed group of Human cerebral cortical neurons derived from iPS cells, with natural electrical and biochemical activities. They overcome the limitations of existing models.

Features

>95% pure neuronal population of primarily GABAergic (inhibitory) neurons
Rapid formation of neural networks and functional synapses
Expression of relevant neurological therapeutic targets and pathways
Long-term viability and demonstrated reproducibility
Reliable supply in cryopreserved format

Cell Types

GABANeuron

Application Notes

Alzheimer's disease research and drug discovery
Functional tau and β-amyloid toxicity pathways, long-term viability, and flexible product format enable high-throughput screening for novel drug candidates
Autism disease research
Demonstrated prefrontal cortex ionotropic glutamate receptors, GABAA receptor, and synaptic functionality drive interrogation of neurological diseases, such as autism
Infectious disease studies
Susceptibility to variNeua zoster virus infection and ability to maintain viral latency and reactivation
Therapeutic potency testing
High sensitivity, dose-response, and biological responses to Clostridium botulinum neurotoxin (BoNT) aid replacement of the gold-standard mouse bioassay for BoNT potency testing
Neurotoxicity assessment
Compatibility with a wide range of high-content, high-throughput platforms enables assessment of pharmaceutical and environmental neurotoxicity

Species

Human
Properties

Size

1 Vial: ≥ 4 x 10^6 cells/vial

Tissue Source

Fibroblast

Age

<18

Mycoplasma Testing

The cell line has been screened using the Mycoplasma Detection Kit to confirm the absence of Mycoplasma contamination.

Shipping

Dry ice.

Storage

Liquid Nitrogen

Research Use Only

For research use only

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Donor Information

Gender

Female

Donor Health

Healthy

Ethnicity

Caucasian
Publications

Publications (0)

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For Research Use Only. Not For Clinical Use.
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