NeuroMab™ Anti-CD33 BBB Shuttle Antibody(NRZP-1022-ZP3557)
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- WB; ELISA; FC; In Vitro; In Vivo
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Species Reactivity
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Research Use Only
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Figure 1 shows an exemplary antibody competition experiment for human CD33 binding between anti-CD33 antibody 15G15 and anti-CD33 antibodies 27C6, 9C2, 33F9, 10D3, 7A1, 15G15, 23E4 and 33H4.
Figure 2 shows that anti-CD33 antibody 9C3 does not compete with anti-CD33 antibody 15G15.33 and binds an epitope different from 15G15.33.
Figure 3 shows that variants of the 9C3 antibody, 9C3.2, 9C3.3 and 9C3.4, have improved binding to huCD33.
Figure 4 shows that anti-CD33 antibodies 7A1, 9C2, 10D3 and 15G15 bind to the Ig-like V domain of huCD33.
Figure 5 shows that the anti-CD33 antibody 15G15 is able to bind the huCD33 Ig-like V domain without N-linked glycosylation.
Figure 6 shows the internalization and in vitro potency of anti-CD33 antibodies 15G15 and 15G15.33 LD#1.
Figure 7 shows the change in tumor volume (mm 3 ) over time after treatment with different doses of 15G15.33 and 15G15.33 Thio-LC V205C LD #1 in HL-60 xenografts.
Figure 8 shows the change in tumor volume (mm3) over time after treatment with different doses of 15G15.33 and 15G15.33 Thio-LC V205C LD #1 in EOL-1 xenografts.
Figure 9 shows the change in tumor volume (mm 3 ) over time after treatment with different concentrations of 15G15 in HL-60 xenografts.
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