NeuroMab™ Anti-Doc2b BBB Shuttle Antibody, Clone N150/21

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-DOC2B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-216 (N-terminus) of rat Doc2b (also known as Double C2-like domaincontaining protein beta and Doc2-beta, accession number P70610)
Mouse: 97% identity (210/216 amino acids identical)
Human: 93% identity (203/169 amino acids identical)
<60% identity with Doc2a

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N150/21

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Doc2a

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

DOC2B

Official Name

DOC2B

Full Name

Doc2b

Alternative Names

Double C2 Domain Beta; Double C2-Like Domains; Beta; Doc2-Beta; DOC2BL; Double C2-Like Domain-Containing Protein Beta; Double C2-Like Domains; Beta-Like;

Uniprot ID

P70610

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged Doc2b or untagged Kv2.1 plasmids and probed with N150/21 (left), N86/8 (middle) and K89/41 (right).