NeuroMab™ Anti-FGFR2; FGFR3 BBB Shuttle Antibody(NRZP-1022-ZP3909)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; WB; In Vitro; In Vivo; Agonist

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

FGFR2FGFR3

Alternative Names

FGFR3; ACH; CD333; CEK2; HSFGFR3EX; JTK4; fibroblast growth factor receptor 3
FGFR2; BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25; fibroblast growth factor receptor 2

Product Pictures

Figure 1 shows the detection of human FGFR2 in SNU-16 xenograft tumors.

Figure 2 shows detection of human FGFR3 in SNU-16 xenograft tumors.

ELISA

Figure 3 shows the binding affinity of the variants to FGFR3 measured by ELISA.

ELISA

Figure 4 shows the binding affinity of the variants to FGFR4 measured by ELISA.

ELISA

Figure 5 shows the FGFR activity of selected anti-FGFR2/3 antibody variants.

ELISA

Figure 6 shows FGFR activity of selected anti-FGFR2/3 antibody variants.

The figure shows FGFR2 activity.

ELISA

Figure 7 shows FGFR activity of selected anti-FGFR2/3 antibody variants.

FGFR4 activity is shown in the figure.

Figure 8 shows the anti-FGFR2/3 antibody variant decision matrix for selecting which anti-FGFR2/3 antibody should be used for the FGFGR2/3+KLB bispecific antibody.

Publications