NeuroMab™ Anti-Fig4/Sac3 BBB Shuttle Antibody, Clone N202/7

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SAC3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 688-907 (C-terminus) of mouse Sac3 (also known as SAC domain-containing protein 3, FIG4 homolog, Polyphosphoinositide phosphatase, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase and Kiaa0274, accession number Q91WF7)
Rat: 95% identity (203/220 amino acids identical)
Human: 91% identity (201/220 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N202/7

Applications

WB; IHC; ICC

Research Areas

Rare Disease

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SAC3

Official Name

FIG4

Full Name

Fig4/Sac3

Alternative Names

FIG4; ALS11; CMT4J; KIAA0274; SAC3; YVS; dJ249I4.1; BTOP; Fig4; FIG4 phosphoinositide 5-phosphatase

Uniprot ID

Q91WF7

Product Pictures

Fig. 1 Immunoblot against adult rat brain membranes (RBM) and samples from wild-type (WT) and Fig4/Sac3 knockout (KO) mice probed with N202/7 (left) and K89/41 (right) TC supe.

Fig. 2 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N202/7 (left) or N52A/42 (right) TC supe.