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Creative Biolabs

NeuroMab™ Anti-Frataxin BBB Shuttle Antibody, Clone N191/7

[CAT#: NRZP-0423-ZP108]

Species Reactivity:
Human; Mouse
Applications:
WB; IHC; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Frataxin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 81-210 (C-terminus) of human Frataxin (also known as Fxn, Friedreich ataxia protein, FRDA and X25, accession number Q16595)
Mouse: 92% identity (118/127 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N191/7

Applications

WB; IHC; ICC

Research Areas

Rare Disease

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

Frataxin

Official Name

FXN

Full Name

Frataxin

Alternative Names

Frataxin; Friedreich Ataxia Protein; FRDA; X25; Frataxin, Mitochondrial; Friedreich Ataxia;

Uniprot ID

Q16595
Product Pictures
IB

Fig. 1 Transfected cell immunoblot: extracts of COS cells transiently transfected with Myc-tagged Frataxin and untagged Kv2.1 plasmids and probed with N191/7 (left), 19E10 (middle) and N52A/42 (right) TC supe.

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