NeuroMab™ Anti-IL-6 BBB Shuttle Antibody(NRZP-1022-ZP2919)
[CAT#: NRZP-1022-ZP2919]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- ELISA; Inhib; In Vitro; In Vivo; Neut
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Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Cynomolgus Monkey
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; Inhib; In Vitro; In Vivo; Neut
Relevant Diseases
Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
IL-6
Official Name
IL6
Full Name
Interleukin 6 (IL-6)
Alternative Names
IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6
Product Pictures
ELISA
Figure 1 Antibody 18E and Antibody 18 in ELISA assay.
FuncS
Figure 2 shows the serum concentrations of antibodies 18 and 18E over time following a single subcutaneous or intravenous administration of a single 5 mg/mL antibody dose.
FuncS
Figure 3 shows serum concentrations of antibodies 18 and 18E over time following subcutaneous administration of a single 5 mg/kg antibody dose.
FuncS
Figure 4 shows the results of 24-h mechanical hyperalgesia.
FuncS
Figure 5 shows the dose-dependent effect of mAb on mechanical stress hypersensitivity in a 24-hour mouse FCA model.
Publications
Publications (0)
Neural Antibodies
Kits
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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