NeuroMab™ Anti-IL-6 Antibody(NRP-0422-P1499)

Product Overview

Description

The isolated IL-6 antagonist antibody prevents IL-6 from binding to gp130, useful for treating IL-6 related diseases based on the IL-6 antagonists.

Immunogen

IL-6/IL-6Ralpha Complex

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse; Humanized; Chimeric

Applications

Antagonist; In Vivo; In Vitro; Block; Inhib

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Gene ID

3569(Human)

Uniprot ID

P05231(Human)

Product Pictures

ELISA

Figure 1 shows the results of experiments reflecting the binding of exemplary antibodies to Fc-IL6Ralpha-IL6.

ELISA

Figure 2 shows the results of experiments reflecting the binding of exemplary antibodies to IL-6.

ELISA

Figure 3 shows the results of experiments reflecting the binding of exemplary antibodies of the invention to non-covalently complexed IL-6 and IL-6Rα.

Block

Figure 4 shows the results of experiments illustrating the ability of exemplary antibodies to block haptoglobin release from HepG2 cells stimulated with Fc-IL6Ralpha-IL6 complexes.