NeuroMab™ Anti-KChIP4 K+ channel BBB Shuttle Antibody, Clone N423/75

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNIP4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-233 (full-length) of human KChIP4 (also known as Kv channel interacting protein 4 isoform CRA_b, A-type potassium channel modulatory protein 4, Potassium channel-interacting protein 4, Calsenilin-like protein, Kcnip4, Calp and mCG_8314, accession number Q3YAB7)
Mouse: 100% identity (233/233 amino acids identical)
Rat:>84% identity (>196/233 amino acids identical)
>80% identity between multiple KChIP4 isoforms
<80% identity with KChIP2 and other KChIP's

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N423/75

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with KChIP1, KChIP2 or KChIP3

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNIP4

Official Name

KCNIP4

Full Name

KChIP4 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Interacting Protein 4; A-Type Potassium Channel Modulatory Protein 4; Kv Channel Interacting Protein 4; Calsenilin-Like Protein; KCHIP4; CALP; Potassium Channel-Interacting Protein 4; Kv Channel-Interacting Protein 4;

Uniprot ID

Q3YAB7

Product Pictures

Fig. 1 Immunoblot against crude membranes from adult rat brain (RBM), mouse brain (MBM) and wild-type (WT) and KChIP4 knockout (KO) mouse brains probed with N423/75 (left) or K55/82 (right) TC supe.

Fig. 2 Immunoblot against adult rat brain membranes (RBM) and extracts of COS cells transiently transfected with untagged KChIP1, KChIP2, KChIP3, KChIP4 or Kv2.1 plasmid probed with N423/75 (left) or K55/82 (right) TC supe.