NeuroMab™ Anti-Kv1.1 potassium channel subunit BBB Shuttle Antibody, Clone K20/78

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Kv1.1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 458-476 (EEDMNNSIAHYRQANIRTG, cytoplasmic C-terminus) of rat Kv1.1 (also known as potassium voltage-gated channel subfamily A member 1, IA, RBKI,RCK1, accession number P10499)
Mouse: 100% identity (18/18 amino acids identical)
Human: 90% identity (16/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K20/78

Applications

WB; IHC; IP; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Kv1.1

Official Name

KCNA1

Full Name

Kv1.1 K+ channel

Alternative Names

KCNA1; AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1; RBK1; potassium voltage-gated channel subfamily A member 1

Uniprot ID

P10499

Product Pictures

Fig. 1 Immunoblot against crude C. elegans worm extracts and crude brain membranes from adult rat (RBM) probed with K20/78 TC supe.

Fig. 2 Immunoblot against crude brain membranes from adult rat (RBM) and Kv1.1 wild-type (WT) or knock-out (KO) mouse probed with K20/78 (left) or N52A/42 (right) TC supe.