NeuroMab™ Anti-Kv1.1 potassium channel (external) BBB Shuttle Antibody, Clone K36/15

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Kv1.1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 191-208 (ELKDDKDFTGTIHRIDNTC, extracellular domain) of rat Kv1.1 (also known as potassium voltage-gated channel subfamily A member 1, IA, RBKI, RCK1, accession number P10499)
Mouse: 100% identity (18/18 amino acids identical)
Human: 94% identity (17/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

K36/15

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Kv1.1

Official Name

KCNA1

Full Name

Kv1.1 K+ channel (external)

Alternative Names

KCNA1; AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MK1; RBK1; potassium voltage-gated channel subfamily A member 1

Uniprot ID

P10499

Product Pictures

Fig. 1 Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)] probed with K36/15 (left) or N52A/42 (right) TC supe.

Fig. 2 Immunoblot against crude brain membranes from adult rat (RBM) and Kv1.1 wild-type (WT) or knock-out (KO) mouse probed with K36/15 (left) or N52A/42 (right) TC supe.

Fig. 3 Immunofluorescence staining of hippocampus from adult Kv1.1 wildtype (left) or knock-out (right) mouse with K36/15 (red) and K13/31 (green, Kv1.4).